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Related Experiment Videos

Review of imipenem.

S Y Park, R H Parker

    Infection Control : IC
    |June 1, 1986
    PubMed
    Summary

    Imipenem is a broad-spectrum antibiotic effective against many bacteria, including Gram-positive and Gram-negative species. While generally well-tolerated, potential side effects include seizures and colonization with resistant organisms.

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    Area of Science:

    • Microbiology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Imipenem is a novel carbapenem beta-lactam antibiotic.
    • It exhibits broad-spectrum activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria.

    Purpose of the Study:

    • To evaluate the in vitro activity of imipenem against various bacterial pathogens.
    • To assess the pharmacokinetic and safety profile of imipenem, particularly when combined with cilastatin.

    Main Methods:

    • In vitro susceptibility testing was performed against a range of clinically relevant bacteria.
    • Pharmacokinetic studies assessed imipenem's serum half-life with and without cilastatin.
    • Clinical efficacy and adverse events were monitored in patient studies.

    Main Results:

    • Imipenem demonstrated high in vitro activity against most bacteria, with minimal inhibitory concentrations (MICs) generally below 2 µg/ml.
    • Enterococci and methicillin-resistant staphylococci showed variable susceptibility.
    • Pseudomonas aeruginosa isolates exhibited a wide range of susceptibility.
    • Combination with cilastatin increased the renal elimination of imipenem's active form.
    • Clinical studies reported efficacy rates between 79% and 96%.

    Conclusions:

    • Imipenem is a potent antibiotic with broad-spectrum activity against many bacterial pathogens.
    • Its pharmacokinetic profile is favorably altered by co-administration with cilastatin.
    • While generally safe, potential adverse effects and resistance development warrant consideration.

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