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White-matter microstructural alterations in patients with functional constipation: A tract-based spatial statistics

Yang Hu¹, Zhenzhen Jia¹, Lei Zhang¹

¹Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.

Neurogastroenterology and Motility

|February 23, 2022

Summary

This summary is machine-generated.

Functional constipation (FC) is linked to white-matter (WM) microstructural changes in the brain, particularly in areas processing sensory and emotional information. These brain alterations may be more associated with psychological symptoms than constipation itself.

Keywords:

diffusion tensor imaging functional constipation track-based spatial statistics white matter

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Area of Science:

Neuroimaging
Gastroenterology
Neurology

Background:

Functional constipation (FC) is a common functional gastrointestinal disorder.
Previous neuroimaging studies show brain functional and morphometric changes in FC patients.
The association between FC and white-matter (WM) microstructural alterations requires further investigation.

Purpose of the Study:

To investigate white-matter (WM) microstructural changes in patients with functional constipation (FC).
To explore the relationship between FC and WM integrity using advanced neuroimaging techniques.

Main Methods:

Diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) were employed.
Microstructural changes were assessed using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD).
The study included 26 FC patients and 31 healthy controls.

Main Results:

FC patients exhibited significantly decreased FA and increased MD/RD in multiple WM tracts, including the corpus callosum (GCC, BCC), cingulum (Cing), anterior corona radiata (ACR), superior corona radiata (SCR), and posterior corona radiata (PCR).
These differences were statistically significant (p_FWE < 0.05).
When accounting for anxiety and depression, significant group differences were primarily observed in the left SCR and PCR.

Conclusions:

The findings suggest an association between FC and WM microstructural abnormalities in brain regions crucial for visceral afferent and emotional-arousal processing.
Alterations in WM tracts like the corpus callosum, cingulum, and ACR may be more strongly linked to psychological symptoms than to constipation itself.
These WM microstructural changes might significantly impact brain structures in individuals with FC.