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Updated: Oct 2, 2025

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Preoperative Risk Factors Affecting Outcome in Surgically Treated Pyogenic Spondylodiscitis
Yuichiro Ukon1, Shota Takenaka1, Takahiro Makino1
1Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Study Design:
Retrospective study.
Objective:
The primary aim of this study was to investigate the predictors of severe complications in patients following surgery for pyogenic spondylodiscitis (PS) using a surgeon-maintained database. The secondary aim was to investigate the predictors of early recovery.
Methods:
We introduced a surgeon-maintained database of prospectively collected multicenter data that mainly focused on perioperative complications in 2012. Our surgeon-maintained database allows the retrospective collection of detailed data. We analyzed 143 patients who underwent surgery for PS from the 19,056 patients in the prospective surgeon-maintained database at 27 affiliated institutions between 2013 and 2017. Data relating to preoperative patient factors, infection factors, surgical factors, and pre- and postoperative blood tests was retrospectively collected. We performed multivariate regression analysis to evaluate the predictors of postoperative severe complications and early recovery in patients with PS.
Results:
High updated Charlson comorbidity index (uCCI), chronic pulmonary disease, diabetes, Gram-negative bacteria, pyogenic osteoarthritis, high preoperative white blood cell count, and low preoperative platelet count were significantly associated with severe complications in patients undergoing surgery for PS. A high uCCI was the sole independent negative predictor on early recovery.
Conclusion:
Careful perioperative management is necessary if surgery is performed on patients who are at a high risk of life-threatening events.
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