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Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Oct 2, 2025

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
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[SCREENING WOMEN AT HIGH RISK FOR BREAST CANCER - BRCA AND BEYOND].

Naama Hermann1,2, Shelley Westergard3, David R McCready1,4

  • 1Department of Surgery, University of Toronto, Toronto, ON, Canada.

Harefuah
|February 23, 2022
PubMed
Summary

High-risk breast cancer screening achieved early diagnosis in women, with MRI being the primary detection method. This highlights the importance of tailored screening programs for women with elevated breast cancer risk.

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Area of Science:

  • Oncology
  • Radiology
  • Genetics

Background:

  • Breast cancer screening aims to reduce morbidity and mortality through early detection.
  • Screening protocols for high-risk women differ, often including yearly mammography and MRI from a younger age.

Purpose of the Study:

  • To evaluate the effectiveness of the High-Risk Ontario Breast Screening Program in achieving early breast cancer diagnosis.
  • To assess morbidity and mortality outcomes in a high-risk screening cohort.

Main Methods:

  • Prospective cohort study of 2,081 women in a high-risk screening program (2011-2018).
  • Data collected included demographics, imaging, biopsies, diagnosis, and treatment.
  • Participants included gene mutation carriers, those with chest radiotherapy history, and others with elevated risk.

Main Results:

  • 89 breast cancer cases were diagnosed, with a median age of 49 and median tumor size of 0.9 cm (T1 disease).
  • MRI was the primary diagnostic tool, identifying most cancers; only 6% were solely mammography-detected.
  • 32% of participants carried pathogenic breast cancer gene variants; 38 women died, primarily BRCA carriers from ovarian cancer.

Conclusions:

  • The high-risk screening program successfully achieved early breast cancer diagnosis.
  • MRI plays a crucial role in detecting breast cancer in high-risk populations.
  • Identifying and referring high-risk women to appropriate screening programs is essential.