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Clobazam: uncontrolled and standard controlled clinical trials
British Journal of Clinical Pharmacology
|January 1, 1979
Summary
Clobazam, a new benzodiazepine, significantly improved anxiety and depression symptoms in patients. It showed comparable effectiveness to diazepam with fewer adverse effects, making it a promising treatment option.
Area of Science:
- Psychiatry
- Clinical Pharmacology
Background:
- Anxiety neurosis and depressive neurosis are common psychiatric conditions.
- Benzodiazepines are frequently used for treating anxiety disorders.
Purpose of the Study:
- To evaluate the efficacy and safety of clobazam in patients with anxiety and depressive neurosis.
- To compare clobazam with diazepam in a controlled clinical setting.
Main Methods:
- An uncontrolled clinical trial involving 11 patients treated with clobazam (10-60 mg daily).
- A standard-controlled clinical study comparing clobazam with diazepam.
- The Hamilton Anxiety Scale (HAM-A) was used to assess therapeutic effectiveness.
Main Results:
- Clobazam treatment resulted in statistically significant improvements in total and factor scores on the HAM-A.
- Optimal clobazam dosage for lowest HAM-A scores was approximately 48-49 mg daily.
- Clobazam demonstrated comparable therapeutic effectiveness to diazepam with a lower incidence of adverse effects.
Conclusions:
- Clobazam is an effective treatment for anxiety and depressive neurosis.
- Clobazam presents a favorable safety profile compared to diazepam.