A Drug Recommendation Model Based on Message Propagation and DDI Gating Mechanism

Drug recommendation task based on the deep learning model has been widely studied and applied in the health care field in recent years. However, the accuracy of drug recommendation models still needs to be improved. In addition, the existing recommendation models either give only one recommendation (however, there may be a variety of drug combination options in practice) or can not provide the confidence level of the recommended result. To fill these gaps, a Drug Recommendation model based on Message Propagation neural network (denoted as DRMP) is proposed in this paper. Then, the Drug-Drug Interaction (DDI) knowledge is introduced into the proposed model to reduce the DDI rate in recommended drugs. Finally, the proposed model is extended to Bayesian Neural Network (BNN) to realize multiple recommendations and give the confidence of each recommendation result, so as to provide richer information to help doctors make decisions. Experimental results on public data sets show that the proposed model is superior to the best existing models.