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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing
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Beyond the Code: Noncoding RNAs in Skin Wound Healing.

Dongqing Li1, Guanglin Niu2, Ning Xu Landén2,3

  • 1Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

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Summary

Noncoding RNAs (ncRNAs) are vital for skin wound healing and complications. This review explores ncRNA roles and their therapeutic potential in wound care.

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Area of Science:

  • Molecular Biology
  • Dermatology
  • Regenerative Medicine

Background:

  • Noncoding RNAs (ncRNAs) regulate gene expression and protein functions.
  • ncRNAs are crucial in biological processes and diseases, including skin wound healing.
  • ncRNAs play pathogenetic roles in chronic nonhealing wounds and excessive scarring.

Purpose of the Study:

  • To review the functional roles of ncRNAs in skin wound healing.
  • To focus on in vivo evidence from human and animal studies.
  • To provide a perspective on ncRNA-based therapeutics for wound care.

Main Methods:

  • Literature review of studies on microRNAs, long ncRNAs, and circular RNAs.
  • Analysis of in vivo evidence from human wound samples.
  • Examination of data from animal wound models.

Main Results:

  • ncRNAs demonstrate critical functions across all stages of skin wound healing.
  • Evidence supports the involvement of ncRNAs in wound complications like chronic nonhealing and scarring.
  • ncRNAs exhibit unique expression and functional properties relevant to wound pathophysiology.

Conclusions:

  • ncRNAs are key regulators in skin wound healing and its complications.
  • ncRNAs represent promising diagnostic and therapeutic targets for wound care.
  • Further research into ncRNA-based therapies holds significant potential for improving wound healing outcomes.