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De-escalation in breast cancer surgery

Sarah P Shubeck1, Monica Morrow2, Lesly A Dossett3

  • 1Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. shubeck@bsd.uchicago.edu.

NPJ Breast Cancer
|February 24, 2022
PubMed
Summary

No abstract available in PubMed .

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...