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Analysis of Neurological Adverse Events Reported in VigiBase From COVID-19 Vaccines
Siddhartha Dutta1, Rimplejeet Kaur2, Jaykaran Charan2
1Department of Pharmacology, All India Institute of Medical Sciences, Rajkot, Rajkot, IND.
Cureus
|February 24, 2022
Summary
COVID-19 vaccines are associated with neurological adverse events (AEs) like dizziness and headache, according to WHO data. Further studies are needed to confirm causality, but vaccination is crucial for pandemic control.
Area of Science:
- Pharmacovigilance
- Neurology
- Vaccinology
Background:
- Emergency approval of COVID-19 vaccines preceded full clinical trials.
- Analysis of neurological adverse events (AEs) following COVID-19 vaccination is critical.
Purpose of the Study:
- To analyze neurological adverse events (AEs) reported post-COVID-19 vaccination.
- To determine the association between specific AEs and COVID-19 vaccines.
Main Methods:
- Utilized WHO pharmacovigilance database (VigiBase) for neurological AE data.
- Extracted data from System Organ Classes: neurological disorders and investigations.
- Employed descriptive statistics and disproportionality analysis (IC0.25).
Main Results:
- 19,529 neurological AEs reported across various COVID-19 vaccines.
- BNT162b2 vaccine had the highest reported AEs, potentially due to widespread use.
- Associated AEs include ageusia, anosmia, dizziness, facial paralysis, headache, seizure, and tremor.
Conclusions:
- Neurological AEs identified require ongoing monitoring and long-term follow-up studies for causality.
- Current findings are not conclusive; mass vaccination remains essential for pandemic control.
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