Related Experiment Video
Updated: Oct 2, 2025
03:20
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
1.2K
Disease Stability in Segmental and Non-Segmental Vitiligo.
Neha Taneja1, V Sreenivas2, Kanika Sahni1
1Department of Dermatology and Venereology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Indian Dermatology Online Journal
|February 24, 2022
Summary
Segmental vitiligo typically becomes inactive after two years of stability, unlike non-segmental vitiligo which may reactivate even after long stable periods. This impacts vitiligo treatment decisions.
Area of Science:
- Dermatology
- Autoimmune Diseases
- Epidemiology
Background:
- Therapeutic decisions for vitiligo are influenced by disease stability.
- Predicting vitiligo inactivity is crucial for patient management.
Purpose of the Study:
- To identify a disease stability period in vitiligo beyond which reactivation is improbable.
- To inform clinical practice regarding vitiligo prognosis.
Main Methods:
- Cross-sectional descriptive study involving 200 vitiligo patients.
- Detailed clinical history of disease activity and stability was recorded.
Main Results:
- Non-segmental vitiligo (83.5%) and segmental vitiligo (16.5%) showed different stability patterns.
- Segmental vitiligo stable for >=2 years was less likely to reactivate (P=0.16).
- No association between stability duration and reactivation risk in non-segmental vitiligo.
Conclusions:
- Segmental vitiligo often achieves inactivity after 2 years of stability.
- Non-segmental vitiligo carries a risk of reactivation irrespective of stability duration.
Related Concept Videos
01:30Skin Cancer
4.8K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.8K
01:23Skin Diseases and Disorders
4.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.4K
01:14Changes in Skin Color: Clinical Perspectives
2.5K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.5K
01:22iPS Cell Differentiation
2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
01:06Multipotency and Niche of Bulge Stem Cell
3.9K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.9K
01:19Pigmentation
3.2K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
3.2K