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Blinding

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.

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Related Experiment Video

Updated: Oct 2, 2025

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

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Published on: August 24, 2019

Exercise-induced Laryngeal Obstruction: Protocol for a Randomized Controlled Treatment Trial.

Hege Clemm^1,2, Ola D Røksund^2,3,4, Tiina Andersen^3,5,6

¹Department of Clinical Science, University of Bergen, Bergen, Norway.

Frontiers in Pediatrics

|February 24, 2022

Summary

This study investigates Exercise-induced laryngeal obstruction (EILO) treatments, comparing non-invasive methods and surgical options. It aims to provide evidence-based guidelines for this common exertional breathing issue in young people.

Keywords:

EILO RCT (randomized controlled trial)VCD exercise protocol treatment

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Published on: December 1, 2023

Area of Science:

Pulmonology
Laryngology
Sports Medicine

Background:

Exercise-induced laryngeal obstruction (EILO) is a frequent cause of exertional breathing difficulties in adolescents and young adults.
EILO is characterized by paradoxical inspiratory adduction of laryngeal structures during high-intensity exercise.
Current EILO treatments lack robust evidence from randomized controlled trials, necessitating further research for guideline development.

Purpose of the Study:

To provide evidence-based information on commonly applied treatment schemes for EILO.
To assess the efficacy of different non-invasive and surgical interventions for EILO.
To address differential treatment effects in predefined EILO subtypes.

Main Methods:

Randomized controlled trial comparing four non-invasive treatments: information/breathing advice (IBA), IBA + inspiratory muscle training, IBA + speech therapy, and IBA + inspiratory muscle training + speech therapy.
Patients not responding to non-invasive treatments may be randomized into surgical arms: standard surgery, minimally invasive laser supraglottoplasty, or no surgery.
Outcomes measured include laryngeal adduction during peak exercise using a validated scoring system before and after interventions.

Main Results:

This section is to be filled once the study is completed and results are available.

Conclusions:

This section is to be filled once the study is completed and conclusions are drawn.