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Association Between Serum Galectin-3 Levels and Coronary Stenosis Severity in Patients With Coronary Artery Disease

Mingxing Li1,2, Kai Guo2, Xuansheng Huang2

  • 1Division of Cardiology, Huiqiao Medical Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Frontiers in Cardiovascular Medicine
|February 24, 2022
PubMed

Insights

Galectin-3 (Gal-3) levels are higher in patients with coronary artery disease (CAD) and correlate with disease severity. Elevated Gal-3 predicts major adverse cardiac events (MACEs) in Acute Coronary Syndrome (ACS) patients, suggesting its prognostic value.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • The association between galectin-3 (Gal-3) and coronary artery disease (CAD) requires further clarification.
  • Gal-3 is a protein implicated in various cardiovascular processes.

Purpose of the Study:

  • To investigate the relationship between serum Gal-3 levels and the presence and severity of CAD.
  • To assess Gal-3 as a predictor of adverse outcomes in CAD patients, particularly those with Acute Coronary Syndrome (ACS).

Main Methods:

  • Serum Gal-3 levels were measured in 331 CAD patients and 62 controls.
  • Comparisons were made between non-CAD and CAD groups, stable CAD and ACS subgroups, and based on SYNTAX scores (SSs).
  • One-year Major Adverse Cardiac Events (MACEs) rates were analyzed in ACS patients stratified by Gal-3 levels.

Main Results:

  • Serum Gal-3 was significantly elevated in CAD patients compared to controls (3.89 vs. 2.07 ng/ml, P < 0.001).
  • Gal-3 levels were higher in ACS subgroups (NSTE-ACS and STEMI) compared to stable CAD.
  • Gal-3 was an independent predictor of ACS (OR=1.131) and high SS (OR=1.030).
  • ACS patients with Gal-3 above the median had higher MACE rates; Gal-3 remained an independent risk factor for MACEs (6% higher incidence per 1 ng/ml increment).

Conclusions:

  • Galectin-3 levels correlate with CAD presence, stability, and complexity.
  • Serum Gal-3 shows potential as a valuable biomarker for predicting mid-term prognosis in ACS patients.
Abstract

Keywords:
acute coronary syndromecoronary artery diseasegalectin-3prognosissyntax score

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