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Cytomegalovirus Infection Is Associated With Increased Prevalence of Latent Tuberculosis Infection
Yuri F van der Heijden1, Bin Zhang2, Claire A Chougnet3
1Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Abstract:
Cytomegalovirus (CMV) increases tuberculosis (TB) risk, but its relationship with latent TB infection (LTBI) is unknown. Using US nationally representative data, we report that CMV was independently associated with LTBI (odds ratio, 2.94; 95% CI, 1.19-7.28; P=.02). CMV and LTBI were associated with higher C-reactive protein, suggesting chronic inflammation.
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