Paracentral acute middle maculopathy following hepatitis B vaccine

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Verena R Juncal1,2, Aditya Bansal1,2, Hesham Hamli1,2

  • 1Department of Ophthalmology, St. Michael's Hospital / Unity Health, Toronto, Canada.

American Journal of Ophthalmology Case Reports
|February 24, 2022
PubMed

Insights

A rare case of paracentral acute middle maculopathy (PAMM) was observed in a child following the Hepatitis B vaccine. Prompt recognition of such rare vaccine-associated ocular complications is crucial.

Area of Science:

  • Ophthalmology
  • Vaccinology
  • Pediatrics

Background:

  • Vaccines are critical for public health.
  • Rare ocular complications can occur following vaccination.
  • Paracentral acute middle maculopathy (PAMM) is a condition affecting the macula.

Observation:

  • A 12-year-old female developed paracentral acute middle maculopathy (PAMM) in her right eye.
  • The onset of PAMM was temporally associated with a recent Hepatitis B vaccination.

Findings:

  • The case highlights a potential, albeit rare, association between Hepatitis B vaccine and PAMM.
  • This emphasizes the need for vigilance regarding vaccine safety and potential adverse events.

Implications:

  • Clinicians should consider vaccine-associated ocular complications in the differential diagnosis of visual disturbances post-vaccination.
  • Further research may be warranted to understand the mechanisms and incidence of vaccine-associated PAMM.
Abstract

Keywords:
Hepatitis B vaccineINL, Inner Nuclear LayerOCT, Optical Coherence TomographyPAMM, Paracentral Acute Middle MaculopathyParacentral acute middle maculopathyRetinal vascular occlusion

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