Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scintigraphic evaluation of liver transplant function.

M K Loken, N L Ascher, R J Boudreau

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |April 1, 1986
    PubMed
    Summary

    Radionuclide imaging using technetium-99m labeled iminodiacetic acid (IDA) derivatives aids in assessing liver function and biliary system health post-liver transplant. These studies evaluate hepatic blood flow, hepatocyte function, and detect potential complications like obstruction or leaks.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neonatal tolerance induction in diabetes-prone BB rats as a model for donor-specific pancreas transplantation during adulthood.

    Transplantation proceedings·1992
    Same author

    Conversion of exocrine secretions from bladder to enteric drainage in recipients of whole pancreaticoduodenal transplants.

    Annals of surgery·1992
    Same author

    20 years or more of follow-up of living kidney donors.

    Lancet (London, England)·1992
    Same author

    Kidney transplantation in diabetic patients: the University of Minnesota experience.

    Kidney international. Supplement·1992
    Same author

    The impact of HLA matching on graft survival.

    Transplantation·1992
    Same author

    Pancreas transplantation--1991.

    Transplantation proceedings·1992

    Area of Science:

    • Hepatobiliary Imaging
    • Nuclear Medicine
    • Transplant Surgery

    Background:

    • Liver transplantation is a complex procedure with potential postoperative complications.
    • Accurate monitoring of liver function and biliary integrity is crucial for patient outcomes.
    • Radionuclide imaging offers a non-invasive method for assessing hepatobiliary function.

    Purpose of the Study:

    • To evaluate the utility of technetium-99m labeled iminodiacetic acid (IDA) derivatives in assessing liver function and biliary system status in liver transplant recipients.
    • To determine the role of IDA scans in monitoring postoperative recovery and detecting complications.

    Main Methods:

    • Seventy-three liver transplant patients underwent radionuclide studies using 99mTc-labeled IDA derivatives (initially PIPIDA, later diisopropyl IDA).

    Related Experiment Videos

  • IDA agents were administered as a bolus for immediate assessment of "flow" and "pooling", followed by sequential imaging up to 24 hours.
  • Analysis included hepatic and bowel patterns of uptake and clearance, arterial and portal venous supply, hepatocyte function, and biliary system assessment.

    • Main Results:

    • IDA scans provided valuable information on hepatic arterial and portal venous supply.
    • The rapidity of hepatic concentration and excretion directly measured hepatocyte function.
    • Sequential scans were useful for monitoring responses to therapy for rejection or infection.
    • The study effectively assessed the biliary system for obstruction or leaks.

    Conclusions:

    • Technetium-99m labeled IDA derivative scintigraphy is a valuable tool for evaluating liver transplant recipients.
    • It provides critical insights into hepatic perfusion, hepatocyte function, and biliary integrity.
    • This imaging modality aids in early detection and management of postoperative complications.