Ying Yang 1 engagement in brain pathology

Area of Science:

• Neuroscience
• Molecular Biology
• Genetics

Background:

• Transcription factor Yin Yang 1 (YY1) is vital for nervous system development, including neurulation and cell differentiation.
• YY1 regulates both neural and glial tissues, and its absence leads to CNS malformations.
• Dysregulation of YY1 is implicated in the pathology of numerous brain disorders.

Purpose of the Study:

• To review the role of transcription factor Yin Yang 1 (YY1) in brain disease development.
• To highlight the pathological mechanisms driven by YY1.
• To explore YY1's potential as a therapeutic target for neurological disorders.

Main Methods:

• Literature review and data synthesis on YY1's function in the nervous system.
• Analysis of YY1's involvement in developmental processes and neuropathology.
• Examination of YY1's role in specific brain diseases such as stroke, epilepsy, Alzheimer's, and Parkinson's.

Main Results:

• YY1 is essential for normal brain development, including neural and glial cell regulation.
• Aberrant YY1 activity is linked to developmental abnormalities and anatomical malformations of the CNS.
• YY1 dysfunction is a key factor in the pathogenesis of stroke, epilepsy, Alzheimer's, Parkinson's, autism, dystonia, and brain tumors.

Conclusions:

• Understanding YY1's complex role in nervous system pathology is critical.
• YY1's involvement in diverse brain diseases underscores its significance.
• Targeting YY1 pathways may offer novel therapeutic strategies for treating brain disorders.