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Safety of intranasal corticosteroids for allergic rhinitis in children

Min Zhang1, Jing-Zi Ni1, Lei Cheng1,2

  • 1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Expert Opinion on Drug Safety
|February 24, 2022
PubMed

Insights

Intranasal corticosteroids (INCSs) are effective for treating allergic rhinitis (AR) in children, showing a good safety profile. Careful patient assessment is recommended to balance benefits and risks.

Area of Science:

  • Pediatric Allergy and Immunology
  • Pharmacology and Therapeutics
  • Nasal Inflammatory Diseases

Background:

  • Allergic rhinitis (AR) is a prevalent chronic inflammatory nasal condition affecting 10-40% of children globally.
  • Intranasal corticosteroids (INCSs) are the primary anti-inflammatory treatment for pediatric AR.
  • Assessing the local and systemic adverse effects of INCSs in children is crucial.

Purpose of the Study:

  • To evaluate the safety and efficacy of intranasal corticosteroids (INCSs) in pediatric allergic rhinitis (AR).
  • To analyze local and systemic adverse effects associated with INCSs in children with AR.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs).
  • Searched PubMed and Embase databases for relevant studies.
  • Focused on studies reporting local and systemic adverse effects in pediatric AR populations.

Main Results:

  • INCSs demonstrate a favorable safety profile in treating pediatric AR.
  • A low incidence of adverse events was observed.
  • INCSs exhibit a beneficial local-to-systemic bioavailability balance.

Conclusions:

  • INCSs are generally safe and effective for pediatric AR.
  • Treatment decisions should be individualized based on patient response and adverse effects.
  • Balancing the benefits and risks of INCSs is essential for optimal clinical outcomes and safety.
Abstract

Keywords:
Allergic rhinitischildintranasal corticosteroidspharmacokineticssafetytolerability

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