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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Related Experiment Video

Updated: Oct 2, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Recurrent Dermatofibrosarcoma Protuberance: A Case Report.

Shiv Raj Shah1, Sujan Regmee1, Dhiresh Kumar Maharjan1

  • 1Department of Surgery, Kathmandu Medical College Teaching Hospital, Sinamangal, Kathmandu, Nepal.

JNMA; Journal of the Nepal Medical Association
|February 24, 2022
PubMed
Summary
This summary is machine-generated.

Dermatofibrosarcoma protuberance is a rare skin cancer. This case highlights a recurrent tumor requiring surgical excision and emphasizes the need for long-term patient follow-up.

Keywords:
adjuvant radiotherapy dermatofibrosarcoma; recurrence; skin grafting.

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Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Dermatofibrosarcoma protuberance (DFSP) is a rare, slow-growing malignant mesenchymal tumor of the skin.
  • DFSP accounts for less than 0.1% of all skin neoplasms.
  • Wide local excision is the primary treatment, but recurrence rates can be significant.

Observation:

  • A 32-year-old male presented with a large (15x6cm) left lumbar swelling.
  • Initial excision three years prior revealed a malignant mesenchymal tumor, histopathologically consistent with DFSP.
  • The patient presented again with a recurrent tumor at the same site after nine months.

Findings:

  • Histopathological examination confirmed a recurrent DFSP.
  • The recurrent tumor was excised with a Split Thickness Skin Graft.
  • Adjuvant radiotherapy was withheld to prevent potential deeper infiltration in future relapses.

Implications:

  • Recurrence of DFSP necessitates vigilant monitoring and management.
  • This case underscores the importance of thorough surgical evaluation and long-term follow-up for DFSP patients.
  • Careful consideration of adjuvant therapies may be warranted in recurrent or aggressive DFSP cases.