Related Experiment Videos
Multiple organ donation: its impact on the recovery of cadaver kidneys
Abstract:
Cyclosporin A not only has improved renal allograft survival but it also has caused a renewed interest in cardiac and hepatic transplantation. The South Texas Organ Bank was sensitive to the need for multiple organ donors and also concerned that the recovery of multiple organs could have a negative impact on the quantity or quality of kidneys recovered. From July 1983 through March 1985 cadaveric kidneys were obtained from 43 renal donors and multiple vital organs were obtained from 11 additional donors. There was no statistical difference between the renal and multiple organ donors in the incidence of renal contamination, post-transplant acute renal failure or renal discard rate (p greater than 0.3 in each comparison). No donor family rescinded permission for renal donation because other vital organs were requested. Urologists involved in cadaveric renal recovery are encouraged to view every cadaver donor as a potential multiple organ donor.
Insights
Recovering multiple organs from deceased donors does not negatively impact kidney recovery. This study found no significant differences in kidney contamination, failure, or discard rates between single and multiple organ donors.
Area of Science:
- Transplantation immunology
- Organ recovery protocols
- Nephrology
Background:
- Cyclosporin A has improved transplant outcomes, increasing demand for cardiac and hepatic transplants.
- The South Texas Organ Bank evaluated the impact of multiple organ recovery on kidney donation.
- Concerns existed regarding potential negative effects on kidney quantity or quality.
Purpose of the Study:
- To assess if multiple organ procurement affects kidney recovery outcomes.
- To compare kidney contamination, failure, and discard rates between renal and multiple organ donors.
- To evaluate donor family consent for multi-organ donation.
Main Methods:
- Analysis of cadaveric kidney recovery data from July 1983 to March 1985.
- Comparison of 43 renal donors with 11 donors from whom multiple vital organs were recovered.
- Statistical analysis of renal contamination, post-transplant acute renal failure, and renal discard rates.
Main Results:
- No statistically significant difference in renal contamination incidence (p > 0.3).
- No statistically significant difference in post-transplant acute renal failure (p > 0.3).
- No statistically significant difference in renal discard rate (p > 0.3).
- No donor families withdrew consent for renal donation due to requests for other organs.
Conclusions:
- Multiple organ recovery does not compromise kidney recovery quantity or quality.
- Cadaveric donors can be viewed as potential multiple organ donors.
- Encourages urologists to consider all cadaver donors for multi-organ recovery.