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Updated: Oct 2, 2025

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
Published on: March 12, 2019
Isotope-selective radiography and material assay using high-brilliance, quasi-monochromatic, high-energy photons
Abstract:
We demonstrate the possibility to directly detect microgram amounts of the isotope 7Li using a quasi-monochromatic high-energy photon beam. The isotope selective detection is based on a witness scatterer absorbing and re-emitting photons via nuclear resonance fluorescence. This enables the detection of isotopes with microgram accuracy at long distances from the actual sample. Further, we demonstrate that the technique can deliver quantitative information without specific knowledge of the photon flux and no spectral capabilities or knowledge of the resonance fluorescence cross section. Detection of low-atomic-weight isotopes screened by heavy shielding is also shown. The techniques described are applicable to all next-generation, ultrahigh brilliance, laser-Compton light sources currently under construction.
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