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[Immune reactions following keratoplasty]
Klinische Monatsblatter Fur Augenheilkunde
|March 1, 1986
Summary
Immune reactions after penetrating keratoplasty occur in 42.8% of cases, with risk factors like anterior synechiae and regrafts increasing severity. Prognosis depends on immune reaction type and clinical context.
Area of Science:
- Ophthalmology
- Immunology
Context:
- Penetrating keratoplasty (corneal transplant) is a common procedure.
- Understanding immune reactions is crucial for graft survival and visual outcomes.
Purpose:
- To analyze different forms of immune reactions following penetrating keratoplasty.
- To investigate the relationship between immune reactions, indication for surgery, and prognosis.
- To identify risk factors associated with immune reactions.
Summary:
- Immune reactions were observed in 42.8% of 236 penetrating keratoplasty cases.
- Epithelial Khodadoust line (7.2%) and subepithelial infiltrates (5.9%) were noted.
- High-risk groups (anterior synechiae, chronic inflammation, regrafts) showed significantly higher rates of severe and irreversible immune reactions.
Impact:
- Identifies key risk factors for graft rejection, including anterior synechiae, chronic inflammation, and regrafts.
- Highlights the prognostic significance of specific immune reactions, particularly endothelial forms.
- Suggests iatrogenic causes in approximately 50% of late immune reactions, emphasizing careful surgical and post-operative management.