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Minoxidil and captopril in severe hypertension
Klinische Wochenschrift
|April 1, 1986
Summary
Minoxidil and captopril effectively treat severe hypertension. Minoxidil showed slightly greater blood pressure reduction but with more side effects than captopril in refractory patients.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Severe hypertension often requires advanced treatment options.
- Patients refractory to conventional therapies need effective alternatives.
Purpose of the Study:
- To compare the antihypertensive efficacy and side effect profiles of minoxidil and captopril.
- To evaluate these drugs in males with essential or renal parenchymatous hypertension resistant to standard treatments.
Main Methods:
- A randomized trial involving 23 males with refractory hypertension.
- Patients received either minoxidil (2.5 mg BID) or captopril (25 mg BID), with dose adjustments and cross-over options.
- Mean observation period was 12 weeks.
Main Results:
- Both drugs significantly reduced systolic and diastolic blood pressure.
- Minoxidil group: 179/114 to 148/92 mmHg. Captopril group: 176/111 to 158/97 mmHg.
- Minoxidil had a higher response rate (75% vs 55%) and significantly more side effects (p < 0.05).
Conclusions:
- Minoxidil and captopril are highly effective for severe, refractory hypertension.
- Minoxidil offers slightly superior blood pressure control but with increased adverse events.
- Captopril provides a viable alternative with a better side effect profile.