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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...

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Related Experiment Video

Updated: Jul 22, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Effect of obstructive sleep apnoea on retinal microvascular function: a randomised controlled trial.

Chris D Turnbull1,2, James A Stockley3, Shyam Madathil3

  • 1Nuffield Department of Medicine, University of Oxford, Oxford, UK. christopher.turnbull@ouh.nhs.uk.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|February 24, 2022
PubMed
Summary

Obstructive sleep apnea (OSA) does not significantly impact retinal microvascular function, even when continuous positive airway pressure (CPAP) is withdrawn. This suggests OSA affects large and small blood vessels differently.

Keywords:
AutoregulationEndothelial functionObstructive sleep apnoeaOcular vascular diseaseRetinal vascular reactivity

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Area of Science:

  • Ophthalmology
  • Sleep Medicine
  • Vascular Biology

Background:

  • Retinal microvascular endothelial dysfunction is implicated in ocular vascular diseases.
  • Obstructive sleep apnea (OSA) is known to cause macrovascular endothelial dysfunction.
  • The specific impact of OSA on retinal microvascular function remains unclear.

Purpose of the Study:

  • To investigate the effect of obstructive sleep apnea (OSA) on retinal microvascular endothelial function.
  • To determine if OSA influences the microvasculature of the retina.

Main Methods:

  • A multi-center, double-blind, randomized controlled trial was conducted.
  • Patients with moderate-to-severe OSA on CPAP were randomized to continue CPAP or use sham CPAP for 14 nights.
  • Retinal vascular responses were measured using dynamic vessel analysis.

Main Results:

  • There was no significant difference in retinal microvascular responses between the continued CPAP and sham CPAP groups.
  • The change in the arteriolar response to flickering light was +3.8 arbitrary units (p=0.59).
  • CPAP withdrawal and the return of OSA did not significantly alter retinal microvascular function.

Conclusions:

  • CPAP withdrawal and the re-emergence of OSA did not significantly affect retinal microvascular responses.
  • This finding contrasts with the known effects of OSA on macrovascular endothelial function.
  • OSA may exert differential effects on macrovascular versus microvascular endothelial function.