Optimizing HIV Prevention Efforts to Achieve EHE Incidence Targets.

Area of Science:

• Public Health
• Epidemiology
• Health Economics

Background:

• The Ending the HIV Epidemic (EHE) initiative aims to decrease new HIV infections by 75% in 5 years and 90% in 10 years.
• A resource allocation analysis was conducted to identify strategies for achieving EHE goals.

Purpose of the Study:

• To analyze current HIV intervention funding and model the impact of increased and optimized resource allocation.
• To determine the necessary funding levels and allocation strategies to meet EHE targets.

Main Methods:

• Estimated current annual societal funding for 14 HIV prevention and treatment interventions.
• Developed scenarios for optimizing and reallocating $2.8 billion/year in funding.
• Analyzed the impact of additional EHE funding from 2021-2030 on projected HIV incidence.

Main Results:

• Without optimization, increased funding alone could reduce annual HIV incidence by 80% by 2030 (36,000 to 7,600 cases).
• With optimized funding starting in 2023, projected annual incidence could decrease to 2,200 cases by 2030.
• Significant increases in resources, even without optimization, show substantial reductions in new HIV infections.

Conclusions:

• Achieving both EHE targets necessitates optimized prevention funding early in the initiative.
• Flexibility in funding allocation across agencies is required for efficient implementation.
• Substantial resource increases can lead to an 80% reduction in HIV incidence, but optimization is key for maximum impact.