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Policy-Driven, Multimodal Deep Learning for Predicting Visual Fields from the Optic Disc and OCT Imaging.

Yuka Kihara1, Giovanni Montesano2, Andrew Chen1

  • 1University of Washington, Department of Ophthalmology, Seattle, Washington.

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Summary
This summary is machine-generated.

A deep learning system accurately predicts visual fields from OCT and disc imaging, improving glaucoma diagnosis. This multimodal approach enhances structure-function mapping for better patient care.

Keywords:
Artificial intelligenceDeep learningGlaucomaOCTPerimetryStructure–functionVisual field

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Glaucoma diagnosis relies on correlating visual field (VF) sensitivity with optic disc structure.
  • Current methods for structure-function mapping can be limited.
  • Deep learning (DL) offers potential for advanced image analysis and prediction.

Purpose of the Study:

  • To develop and validate a deep learning system for predicting visual field sensitivity at each point.
  • To derive a structure-function map using optical coherence tomography (OCT) and optic disc imaging.
  • To fuse predictions from single-modality DL models for improved accuracy.

Main Methods:

  • Retrospective study of 6437 patients with glaucoma.
  • Paired OCT and infrared reflectance (IR) optic disc images with VF data within 7 days.
  • Trained EfficientNet B2 DL models for single-modality prediction and a policy DL model for fusion.

Main Results:

  • A multimodal, policy DL model significantly improved prediction accuracy (PMAe) compared to single modalities.
  • The fusion model showed statistically significant improvements (P < 0.0001).
  • Occlusion masking confirmed data-driven, feature-agnostic learning of structure-function relationships.

Conclusions:

  • The multimodal policy DL model demonstrated superior performance in predicting visual fields.
  • The system provides explainable confidence maps for data fusion.
  • This approach offers a novel pathway for investigating the structure-function relationship in glaucoma.