Related Experiment Video

Updated: Oct 2, 2025

Expansion and Enrichment of Gamma-Delta γδ T Cells from Apheresed Human Product
11:51

Expansion and Enrichment of Gamma-Delta γδ T Cells from Apheresed Human Product

Published on: September 22, 2021

9.3K

The Mysterious Actor-γδ T Lymphocytes in Chronic Lymphocytic Leukaemia (CLL)

Michał K Zarobkiewicz1, Agnieszka A Bojarska-Junak1

  • 1Department of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.

Cells
|February 25, 2022
PubMed

Insights

Chronic lymphocytic leukemia (CLL) involves abnormal B cells. This review explores the potential of dysfunctional gamma-delta T cells in CLL immunotherapy, despite the disease remaining incurable.

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • Chronic lymphocytic leukemia (CLL) is a prevalent B-cell malignancy in adults.
  • Current treatments offer progress but have not achieved a cure for CLL.
  • Gamma-delta (γδ) T cells are a distinct subset of cytotoxic T lymphocytes.

Purpose of the Study:

  • To review the current understanding of γδ T lymphocytes in the context of CLL.
  • To explore the potential of γδ T cells for immunotherapy in CLL patients.

Main Methods:

  • Literature review of studies on γδ T cells and CLL.
  • Analysis of γδ T cell function and characteristics in CLL patients.

Main Results:

  • γδ T cells in CLL exhibit functional impairments.
  • Despite dysfunction, γδ T cells represent a potential avenue for novel immunotherapies.

Conclusions:

  • Understanding γδ T cell biology in CLL is crucial for developing new therapeutic strategies.
  • Immunotherapy targeting γδ T cells may offer future treatment options for incurable CLL.

Keywords:
CLLVδ1Vδ2Vδ3chronic lymphocytic leukaemiacytotoxicityγδ T

More Related Videos

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

21.6K
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

10.0K

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.5K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
7.4K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
3.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
5.3K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
8.5K