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Related Experiment Video

Updated: Jun 29, 2026

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

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Published on: August 27, 2014

Controlled Release in Hydrogels Using DNA Nanotechnology.

Chih-Hsiang Hu¹, Remi Veneziano¹

¹Department of Bioengineering, College of Engineering and Computing, George Mason University, Manassas, VA 20110, USA.

|February 25, 2022

Summary

This summary is machine-generated.

This study introduces a novel DNA nanotechnology system integrated into gelatin hydrogels. This innovation enables precise, temporally controlled release of biomolecules, mimicking natural biological signals for advanced biomedical applications.

Keywords:

DNA nanotechnology gelatin hydrogel strand displacement temporal release

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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Area of Science:

Biomaterials Science
Nanotechnology
Biomedical Engineering

Background:

Gelatin hydrogels are crucial for tissue engineering and 3D bioprinting but lack precise temporal control over biomolecule release.
Mimicking native biological signals requires sophisticated control over the sequential distribution of biomolecules, which current hydrogels cannot achieve.

Purpose of the Study:

To develop a novel hydrogel system with precise temporal control over biomolecule release using DNA nanotechnology.
To create a functional release circuit within gelatin hydrogels that closely mimics biological sequential distribution.

Main Methods:

Designed and synthesized multi-arm DNA motifs for conjugation into gelatin hydrogels via click chemistry.
Incorporated a DNA strand displacement circuit within the hydrogel to control cargo release.
Validated DNA motif stability and demonstrated temporal release of model cargos using specific trigger strands.

Main Results:

Successfully conjugated DNA motifs into gelatin hydrogels, enhancing their stability against degradation.
Demonstrated temporally specific release of multiple model cargos by introducing specific trigger strands.
Showcased the ability to modulate cargo release rate and quantity by adjusting trigger strand sequences.

Conclusions:

The developed DNA-gated gelatin hydrogel system offers precise temporal control over biomolecule release.
This system provides a versatile platform for mimicking complex biological signaling pathways for advanced biomedical applications.
The integration of DNA nanotechnology into hydrogels opens new avenues for sophisticated drug delivery and tissue engineering strategies.