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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
Neuroimaging of Mouse Models of Alzheimer's Disease
Amandine Jullienne1, Michelle V Trinh1, Andre Obenaus1
1Department of Pediatrics, University of California, Irvine, CA 92697, USA.
Abstract:
Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made great strides in the diagnosis and our understanding of Alzheimer's Disease (AD). Despite the knowledge gained from human studies, mouse models have and continue to play an important role in deciphering the cellular and molecular evolution of AD. MRI and PET are now being increasingly used to investigate neuroimaging features in mouse models and provide the basis for rapid translation to the clinical setting. Here, we provide an overview of the human MRI and PET imaging landscape as a prelude to an in-depth review of preclinical imaging in mice. A broad range of mouse models recapitulate certain aspects of the human AD, but no single model simulates the human disease spectrum. We focused on the two of the most popular mouse models, the 3xTg-AD and the 5xFAD models, and we summarized all known published MRI and PET imaging data, including contrasting findings. The goal of this review is to provide the reader with broad framework to guide future studies in existing and future mouse models of AD. We also highlight aspects of MRI and PET imaging that could be improved to increase rigor and reproducibility in future imaging studies.
Insights
Magnetic resonance imaging (MRI) and positron emission tomography (PET) are crucial for Alzheimer's Disease (AD) research. This review focuses on preclinical neuroimaging in mouse models, enhancing understanding and translation to human AD diagnosis.
Area of Science:
- Neuroscience
- Medical Imaging
- Alzheimer's Disease Research
Background:
- Alzheimer's Disease (AD) diagnosis and understanding have advanced with human neuroimaging.
- Mouse models are vital for studying AD's cellular and molecular progression.
- MRI and PET are increasingly used in mouse models for translational research.
Purpose of the Study:
- To review human MRI and PET imaging in Alzheimer's Disease.
- To provide an in-depth overview of preclinical neuroimaging in mouse models of AD.
- To guide future research in existing and novel AD mouse models.
Main Methods:
- Comprehensive literature review of published MRI and PET imaging data.
- Focus on two prominent mouse models: 3xTg-AD and 5xFAD.
- Analysis of contrasting findings within the selected mouse models.
Main Results:
- Overview of human MRI and PET imaging landscape for AD.
- Summary of MRI and PET data in 3xTg-AD and 5xFAD mouse models.
- Identification of limitations and areas for improvement in preclinical AD imaging.
Conclusions:
- No single mouse model fully recapitulates the human Alzheimer's Disease spectrum.
- Preclinical neuroimaging in mice offers a basis for clinical translation.
- Improvements in MRI and PET imaging are needed for increased rigor and reproducibility in AD research.
