Related Experiment Video

Updated: Oct 2, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.6K

The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer

Assiya Kussainova1,2, Olga Bulgakova2, Akmaral Aripova2

  • 1Department of Health Sciences, University of Genova, Via Pastore 1, 16132 Genoa, Italy.

Biomedicines
|February 25, 2022
PubMed

Insights

Mitochondrial microRNAs (miRNAs) play a role in lung cancer development. This review explores how these molecules, potentially influenced by radon exposure, contribute to lung cancer pathogenesis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs regulate gene expression post-transcriptionally.
  • Mitochondria possess their own unique microRNAs (miRNAs) that regulate mitochondrial function.
  • Mitochondrial dysfunction is implicated in various diseases, including cancer.

Purpose of the Study:

  • To review the role of mitochondrial miRNAs in lung cancer pathogenesis.
  • To investigate the specific influence of radon exposure on mitochondrial miRNAs in lung cancer.

Main Methods:

  • Literature review of studies on mitochondrial miRNAs and lung cancer.
  • Analysis of research linking environmental factors like radon to mitochondrial dysfunction and cancer.

Main Results:

  • Mitochondrial miRNAs directly regulate mitochondrial genes and cellular activity.
  • Dysregulation of mitochondrial miRNAs is associated with cancer development.
  • Radon exposure may influence mitochondrial miRNA expression, contributing to lung cancer.

Conclusions:

  • Mitochondrial miRNAs are critical regulators of mitochondrial function and cellular homeostasis.
  • Their dysregulation presents a potential mechanism in lung cancer pathogenesis.
  • Further research into radon's impact on mitochondrial miRNAs is warranted for understanding lung cancer etiology.
Keywords:
lung cancermicroRNAmitochondrial microRNAradon

More Related Videos

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines07:49

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

2.7K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.2K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
15.2K
Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
12.6K
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.4K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
8.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K