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Correction: Coulter et al. OrgTRx: A Platform Developed in Queensland for the Extraction and Visualisation of Antimicrobial Susceptibility Data for the Surveillance of Resistance in Microorganisms. <i>Antibiotics</i> 2026, <i>15</i>, 63.

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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
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Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds.

Israel Rodríguez1, Lauren Fernández-Vega1, Andrea N Maser-Figueroa1

  • 1Department of Chemistry, University of Puerto Rico-Río Piedras Campus, San Juan 00925, Puerto Rico.

Antibiotics (Basel, Switzerland)
|February 25, 2022
PubMed
Summary
This summary is machine-generated.

Researchers explored titanium(IV) complexes for new antibiotics against drug-resistant bacteria. Ti(deferasirox)2 showed promise against methicillin-resistant Staphylococcus aureus with low human cell toxicity, suggesting a novel metal-based antimicrobial strategy.

Keywords:
iron chelationtitanium(IV) antimicrobial compoundstransmetalation

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Area of Science:

  • Medicinal Chemistry
  • Inorganic Chemistry
  • Microbiology

Background:

  • Antimicrobial resistance is a growing global health threat, necessitating novel therapeutic strategies.
  • Metal-based compounds are being investigated as potential antimicrobial agents by targeting essential metal bioavailability in microbes.
  • Titanium(IV) complexes represent an underexplored area for antimicrobial drug discovery.

Purpose of the Study:

  • To screen titanium(IV) complexes for antimicrobial activity against drug-resistant pathogens.
  • To evaluate the cytotoxicity of these compounds on human non-cancer cell lines.
  • To investigate the potential mechanism of action for promising titanium(IV) complexes.

Main Methods:

  • Screening of eight Ti(IV) complexes and ligands for antimicrobial activity using the Community for Open Antimicrobial Drug Discovery.
  • Assessment of compound solution stability and ligand exchange lability at pH 7.4.
  • Evaluation of Ti(deferasirox)2 for transmetalation with Fe(III) and inhibition of Fe bioavailability.

Main Results:

  • Ti(deferasirox)2 demonstrated significant inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA).
  • The compound exhibited minimal toxicity towards human non-cancer cell lines.
  • Solution behavior analysis provided insights into the structure-activity relationship of Ti(IV) complexes.

Conclusions:

  • Ti(deferasirox)2 is a promising candidate for further development as an antimicrobial agent against Gram-positive bacteria.
  • The mechanism may involve iron chelation and inhibition of ribonucleotide reductase, disrupting essential microbial processes.
  • Metal-based compounds, particularly titanium complexes, warrant further investigation for combating antimicrobial resistance.