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Related Experiment Video

Updated: Oct 2, 2025

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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Clostridioides Difficile Enteritis: Case Report and Literature Review.

Artsiom Klimko1, Cristian George Tieranu2,3, Ana-Maria Curte4

  • 1Division of Physiology and Neuroscience, "Carol Davila" University of Medicine and Pharmacy, 050747 Bucharest, Romania.

Antibiotics (Basel, Switzerland)
|February 25, 2022
PubMed
Summary

Clostridioides difficile infection can cause severe diarrhea and dehydration in patients with ileostomies. Oral vancomycin effectively treated a case of high-output ileostomy caused by this infection.

Keywords:
Clostridioides difficiledehydrationenteritisileostomy

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Microbiology

Background:

  • Clostridioides difficile (C. diff) commonly causes infectious colitis.
  • Enteritis due to C. diff is less common, primarily reported in ileostomy patients, leading to dehydration.
  • This case highlights a specific presentation of C. diff infection in an ileostomy.

Purpose of the Study:

  • To report a case of Clostridioides difficile enteritis causing high-output ileostomy.
  • To investigate the efficacy of oral vancomycin in treating this condition.
  • To review existing literature on localized C. diff infections in ileostomies.

Main Methods:

  • Case report of a 46-year-old male patient with Crohn's disease and a double ostomy.
  • Identification of Clostridioides difficile toxin A in ileal output.
  • Treatment with oral vancomycin.

Main Results:

  • The patient presented with a high-output ileostomy.
  • Clostridioides difficile toxin A confirmed acute enteritis.
  • Oral vancomycin led to a rapid decrease in ileostomy output volume.

Conclusions:

  • Clostridioides difficile can cause high-output ileostomy.
  • Oral vancomycin is an effective treatment for this condition.
  • Further literature review supports this localized infection presentation.