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Hyperbaric oxygen therapy in chronic stable multiple sclerosis: double-blind study.

G D Harpur, R Suke, B H Bass

    Neurology
    |July 1, 1986
    PubMed
    Summary
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    Hyperbaric oxygen therapy (HBO) did not improve outcomes for patients with chronic stable multiple sclerosis (MS). This randomized trial found no significant differences between HBO and placebo groups in disability or MRI measures.

    Area of Science:

    • Neurology
    • Hyperbaric Medicine

    Background:

    • Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system.
    • Hyperbaric oxygen therapy (HBO) involves breathing pure oxygen in a pressurized chamber, with potential anti-inflammatory and neuroprotective effects.

    Purpose of the Study:

    • To evaluate the efficacy of hyperbaric oxygen therapy (HBO) in treating patients with chronic stable multiple sclerosis (MS).

    Main Methods:

    • A randomized, double-blind, placebo-controlled trial was conducted with 82 patients with chronic stable MS.
    • Participants received either 20 daily HBO treatments (100% O2) or placebo (air) treatments.
    • Follow-up included booster treatments and assessments of disability, MRI, and evoked potentials.

    Main Results:

    Related Experiment Videos

    • No significant differences were observed between the HBO and placebo groups in Extended Kurtzke Disability scores or Kurtzke Functional scores.
    • Magnetic resonance imaging (MRI) and evoked potential measures also showed no significant treatment effects.
    • These findings remained consistent after the initial 20 treatments and subsequent booster sessions.

    Conclusions:

    • Hyperbaric oxygen therapy (HBO) is not effective in treating chronic stable multiple sclerosis (MS).
    • Further research may be needed to explore HBO in different stages or subtypes of MS, but current evidence does not support its use.