SARS-CoV-2 Viral RNA Is Detected in the Bone Marrow in Post-Mortem Samples Using RT-LAMP

Area of Science:

• Virology
• Pathology

Background:

• Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in various human tissues since its emergence.
• Understanding the systemic spread of SARS-CoV-2 is crucial for patient management.

Observation:

• This study examined post-mortem samples from two individuals diagnosed with SARS-CoV-2.
• Samples included nasopharyngeal region, vitreous humor, cerebrospinal fluid, and bone marrow.

Findings:

• SARS-CoV-2 RNA was detected in bone marrow samples from both deceased patients.
• Vitreous humor and cerebrospinal fluid samples tested negative for SARS-CoV-2 RNA.
• The detection of viral RNA in bone marrow was confirmed using the Genomtec® SARS-CoV-2 EvaGreen® RT-LAMP CE-IVD Duo Kit.

Implications:

• The presence of SARS-CoV-2 RNA in bone marrow supports the systemic nature of the infection.
• Systemic viral spread has significant implications for diagnostic testing strategies.
• Understanding systemic infection is vital for improving patient survival rates and treatment protocols.