Related Experiment Video
Updated: Oct 2, 2025
06:17
A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
12.1K
Novel Nutraceutical Compounds in Alzheimer Prevention
Ricardo Benjamin Maccioni1,2, Camila Calfío1,2, Andrea González1,2
1International Center for Biomedicine ICC, Vitacura 3568, Santiago 7630000, Chile.
Biomolecules
|February 25, 2022
Summary
Preventing Alzheimer's disease (AD) involves early detection and lifestyle interventions. Natural agents, like nutraceuticals, show promise in mitigating AD's impact and cognitive decline.
Area of Science:
- Neuroscience
- Gerontology
- Pharmacology
Background:
- Alzheimer's disease (AD) incidence is rising globally, necessitating proactive prevention strategies.
- Pathological changes in AD begin decades before symptom onset, highlighting the need for early detection.
- Molecular biomarkers are crucial for identifying early pathological signs, enabling timely interventions.
Purpose of the Study:
- To review the role of healthy lifestyles and natural agents in Alzheimer's disease prevention.
- To emphasize the importance of early detection through molecular biomarkers for effective intervention.
- To highlight nutraceuticals as key components in managing and preventing dementia, particularly AD.
Main Methods:
- Review of clinical studies on lifestyle interventions and natural compounds.
- Analysis of research on molecular biomarkers for early AD detection.
- Examination of the mechanisms of action for anti-inflammatory and anti-aggregation agents.
Main Results:
- Healthy lifestyles, including exercise and cognitive stimulation, positively impact AD prevention.
- Nutraceuticals, such as quercetin and hydroxytyrosol, possess anti-aging and potential anti-AD properties.
- Specific compounds like biocurcumin and rosemarinic acid demonstrate anti-inflammatory and anti-aggregation effects relevant to AD.
Conclusions:
- Early preventive interventions, informed by biomarker data, can significantly reduce AD cases.
- Nutraceuticals rich in antioxidants and anti-inflammatory compounds are vital for AD prevention and control.
- A multi-faceted approach combining lifestyle changes and targeted natural agents is essential for combating the growing AD epidemic.
Keywords:
AD preventionbioactive molecules derived from plants in ADinterventional approaches toward Alzheimer´s treatmentmechanisms of action in AD therapynutraceutical compoundsvitamins and cofactors actions in ADMore Related Videos
08:27Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
Published on: July 29, 2018
12.1K
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.6K
Related Concept Videos
01:22Alzheimer's Disease: Treatment
279
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
279
01:26Alzheimer's Disease: Overview
713
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
713
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
221
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
221
01:30Dementia
204
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
204
01:29Drugs Affecting Neurotransmitter Synthesis
1.6K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.6K