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In vivo Optogenetic Stimulation of the Rodent Central Nervous System
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Advances in Ophthalmic Optogenetics: Approaches and Applications.

Philipp P Prosseda1, Matthew Tran1,2, Tia Kowal1,3

  • 1Department of Ophthalmology, Stanford University School of Medicine, 1651 Page Mill Road, Palo Alto, CA 94305, USA.

Biomolecules
|February 25, 2022
PubMed
Summary
This summary is machine-generated.

Optogenetics offers new hope for vision restoration in degenerative eye diseases like glaucoma and retinitis pigmentosa by using light to control cells. This approach aims to restore sight by targeting retinal neurons, regardless of the disease

Keywords:
degenerative eye diseasesglaucomaoptogeneticsretinitis pigmentosa

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Biotechnology

Background:

  • Degenerative eye diseases, including glaucoma and retinitis pigmentosa, cause significant vision loss.
  • Current treatments are limited, necessitating novel therapeutic strategies.
  • Optogenetics presents a promising new avenue for vision restoration.

Purpose of the Study:

  • To review recent advances in optogenetics for treating retinal degeneration and glaucoma.
  • To discuss optogenetic molecules, vectors, and applications.
  • To summarize preliminary results from ongoing clinical trials for visual restoration.

Main Methods:

  • Optogenetic techniques involve using light to control cellular activity.
  • Therapeutic strategies focus on replacing lost photoreceptors by inserting light-sensitive proteins into retinal neurons.
  • Pre-clinical and clinical trials are evaluating the safety and efficacy of these approaches.

Main Results:

  • Optogenetic therapies are being explored in pre-clinical and clinical trials for major blinding diseases.
  • Approaches are genetic-agnostic, potentially treating all forms of retinal degeneration.
  • The CRY-CIBN system has been applied to glaucoma models, implicating OCRL in intraocular pressure regulation.

Conclusions:

  • Optogenetics holds significant promise for vision restoration in degenerative eye diseases.
  • These strategies offer a potential treatment for a wide range of retinal conditions.
  • Further research and clinical trials are crucial to realize the full therapeutic potential.