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Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer.

Sarah Koushyar1,2, Valerie S Meniel1, Toby J Phesse1,3

  • 1The European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Cardiff CF24 4HQ, UK.

Biomolecules
|February 25, 2022
PubMed
Summary
This summary is machine-generated.

Aberrant Wnt pathway activation drives prostate cancer growth, metastasis, and resistance. Targeting this pathway shows promise for treatment, but its role across cancer stages requires further research.

Keywords:
APCCRPCWntmetastasisprostate cancertargeted therapyβ-catenin

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Aberrant Wnt pathway activation is common in prostate cancer.
  • This activation contributes to tumor formation, progression, and therapeutic resistance.
  • Understanding Wnt signaling's role is key for effective prostate cancer treatment.

Purpose of the Study:

  • To review genetic alterations activating Wnt signaling in prostate cancer.
  • To highlight laboratory models for studying Wnt drivers in prostate cancer.
  • To discuss mechanisms of Wnt cascade in prostate cancer growth, metastasis, and drug resistance.

Main Methods:

  • Literature review of genetic alterations.
  • Analysis of preclinical laboratory models.
  • Mechanistic insights into Wnt pathway signaling.

Main Results:

  • Identified genetic alterations leading to Wnt pathway activation.
  • Summarized various laboratory models used in research.
  • Discussed Wnt cascade's role in tumor progression and resistance.

Conclusions:

  • Targeting the Wnt pathway is a potential therapeutic strategy for prostate cancer.
  • Further preclinical research is crucial to understand Wnt signaling across all cancer stages.
  • Identifying effective strategies and biomarkers requires deeper molecular understanding.