Preoperative Stereotactic Radiosurgery for Glioblastoma.

Area of Science:

• Neuro-oncology
• Radiation Oncology
• Immunology

Background:

• Glioblastoma (GBM) remains a lethal brain tumor with limited survival improvements.
• Modern treatments reduce toxicity but haven't significantly changed GBM prognosis.
• Previous adjuvant stereotactic radiosurgery (SRS) for GBM yielded poor results.

Purpose of the Study:

• To review glioblastoma (GBM) and explore the potential of preoperative stereotactic radiosurgery (SRS).
• To discuss the immunogenic effects of preoperative SRS in the context of GBM.
• To evaluate the largely unknown role of preoperative SRS in GBM treatment.

Main Methods:

• Literature review of glioblastoma (GBM) and stereotactic radiosurgery (SRS).
• Analysis of SRS properties: conformal radiation, high doses, few sessions, tissue sparing.
• Exploration of radiation's impact on central nervous system anti-tumor immunity.

Main Results:

• Preoperative SRS may allow for smaller treatment volumes on intact tumors.
• SRS in the preoperative setting might reduce risks of leptomeningeal disease and radiation necrosis.
• The immunogenic effects of preoperative SRS on GBM are under investigation.

Conclusions:

• Preoperative SRS is a novel approach for glioblastoma (GBM) with potential benefits.
• SRS may enhance anti-tumor immunity, warranting further study in GBM.
• The role and immunomodulatory impact of preoperative SRS in GBM require further research.