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Updated: Oct 2, 2025
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In vitro Organoid Culture of Primary Mouse Colon Tumors
Published on: May 17, 2013
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Discoidin Domain Receptor 1 Expression in Colon Cancer: Roles and Prognosis Impact
Kaouther Ben Arfi1, Christophe Schneider2, Amar Bennasroune2
1Laboratoire de Biopathologie, Centre Hospitalier Universitaire de Reims, 51090 Reims, France.
Cancers
|February 25, 2022
Summary
Discoidin Domain Receptor 1 (DDR1) is highly expressed in most colon cancers, correlating with poorer event-free survival. This suggests DDR1
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Extracellular matrix components, like collagens, are crucial in the tumor microenvironment, influencing tumor progression and metastasis.
- Discoidin Domain Receptor 1 (DDR1) is a receptor tyrosine kinase implicated in cell-matrix interactions and cancer development.
Purpose of the Study:
- To investigate the clinical and prognostic significance of Discoidin Domain Receptor 1 (DDR1) expression in colon cancer.
- To explore the association of DDR1 expression with specific molecular and morphological profiles in colon adenocarcinomas.
- To assess DDR1's potential as a prognostic biomarker in colon cancer.
Main Methods:
- Immunohistochemistry was used to evaluate DDR1 expression in 292 colonic adenocarcinoma samples.
- Laser capture microdissection analyzed DDR1 mRNA expression in tumor and stromal cells.
- Modified Boyden chamber assays assessed the impact of DDR1 on colon adenocarcinoma cell invasion.
Main Results:
- High DDR1 expression was observed in 82.2% of colon adenocarcinomas.
- High DDR1 immunostaining correlated with male sex, left-sided tumors, BRAF wild-type, KRAS mutated status, and Annexin A10 negativity.
- High DDR1 expression was significantly associated with shorter event-free survival.
- DDR1 mRNA expression was predominantly found in adenocarcinoma cells, not stromal cells.
- DDR1 expression was shown to support the invasive capacity of colon adenocarcinoma cells.
Conclusions:
- Discoidin Domain Receptor 1 (DDR1) is frequently overexpressed in colon adenocarcinomas.
- High DDR1 expression serves as an indicator of worse event-free survival in colon cancer patients.
- DDR1 plays a role in supporting colon adenocarcinoma cell invasion.
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