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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Spontaneous Murine Model of Anaplastic Thyroid Cancer
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Anaplastic Thyroid Carcinoma: An Update.

Arnaud Jannin1,2, Alexandre Escande2,3, Abir Al Ghuzlan4

  • 1Department of Endocrinology, Diabetology, Metabolism and Nutrition, Lille University Hospital, 59000 Lille, France.

Cancers
|February 25, 2022
PubMed
Summary
This summary is machine-generated.

Anaplastic thyroid carcinoma (ATC) is a rare cancer with poor prognosis. Systematic molecular testing and dedicated care pathways may double patient survival times.

Keywords:
anaplastic thyroid carcinomachemotherapyimmune checkpoint inhibitorsmolecular targeted therapyradiotherapytumors associated macrophages

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Anaplastic thyroid carcinoma (ATC) is an aggressive, undifferentiated thyroid cancer with a median survival of 4-10 months.
  • Current management strategies often lead to delayed diagnosis and treatment, contributing to poor outcomes.

Purpose of the Study:

  • To review current knowledge on anaplastic thyroid carcinoma.
  • To provide perspectives on improving patient management and outcomes through systematic molecular testing and integrated care pathways.

Main Methods:

  • Review of current literature on ATC diagnosis and treatment.
  • Analysis of the impact of molecular testing and multidisciplinary care on survival.
  • Discussion of therapeutic strategies including surgery, chemotherapy, targeted therapy, and radiotherapy.

Main Results:

  • Systematic molecular testing for targeted therapies can potentially double overall survival (OS) in ATC patients.
  • Fast-track dedicated care pathways in tertiary centers are crucial for timely diagnosis and treatment initiation.
  • Multidisciplinary team meetings are essential for defining personalized therapeutic management.

Conclusions:

  • Improved diagnostic confirmation through expert pathology and molecular analyses is vital.
  • Prompt initiation of treatment, within days of diagnosis, is critical.
  • Adjuvant chemo-radiotherapy for localized disease and chemotherapy or targeted therapy with radiotherapy for advanced/metastatic disease are recommended approaches.