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Related Concept Videos

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
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G-Protein Gated Ion Channels01:21

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GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
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The Role of Ion Channels in Neuronal Computation01:19

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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
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Ligand-gated Ion Channels01:19

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Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
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Related Experiment Video

Updated: Oct 2, 2025

Recapitulation of an Ion Channel IV Curve Using Frequency Components
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Acid-Sensing Ion Channel 2: Function and Modulation.

Andy Sivils1, Felix Yang1, John Q Wang1

  • 1Department of Biomedical Sciences, School of Medicine, University of Missouri, Kansas City, MO 64108, USA.

Membranes
|February 25, 2022
PubMed
Summary
This summary is machine-generated.

Acid-sensing ion channels (ASICs) play key roles in the body. This review highlights the understudied ASIC2 subunit

Keywords:
ASIC2acid-sensing ion channelsfunctionmodulationpathologypharmacologyphysiology

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Physiology

Background:

  • Acid-sensing ion channels (ASICs) are crucial in human health and disease.
  • ASICs are part of the degenerin/epithelial sodium channel family, with multiple subunits forming various channel complexes.
  • ASIC1a and ASIC1a/2 heterotrimers are prevalent in the central nervous system (CNS).

Purpose of the Study:

  • To review the lesser-examined ASIC2 subunits in the context of health and disease.
  • To explore ASIC2's role in modulating ASIC channel function and synaptic targeting.
  • To discuss ASIC2's involvement in cardiovascular responses and its pharmacological properties.

Main Methods:

  • Literature review focusing on ASIC2 function and implications.
  • Analysis of existing research on ASIC2 in various physiological and pathological conditions.
  • Synthesis of evidence regarding ASIC2's role in neurological and cerebrovascular diseases.

Main Results:

  • ASIC2 influences ASIC channel modulation and synaptic localization.
  • ASIC2 plays a role in cardiovascular regulation.
  • Evidence links ASIC2 to pathologies including ischemic brain injury, epilepsy, and drug addiction.

Conclusions:

  • ASIC2 is a critical but understudied component of the ASIC family.
  • ASIC2's diverse roles in the CNS and periphery suggest broad physiological and pathological relevance.
  • The ASIC2 protein represents a promising therapeutic target for neurological, psychological, and cerebrovascular disorders.