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Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular

Jędrzej Sarnecki1, Agata Paszkowska2, Joanna Petryka-Mazurkiewicz3,4

  • 1Department of Diagnostic Imaging, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.

Journal of Clinical Medicine
|February 25, 2022
PubMed

Insights

Pediatric left ventricular non-compaction (LVNC) is linked to enlarged left ventricles and impaired function. Children with LVNC also show increased right ventricular trabeculations and subclinical myocardial deformation.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Cardiovascular Imaging

Background:

  • Left ventricular non-compaction (LVNC) is a rare cardiomyopathy primarily affecting the left ventricle (LV), but can involve the right ventricle (RV).
  • Understanding the impact of LVNC on both ventricles in pediatric populations is crucial for diagnosis and management.

Purpose of the Study:

  • To evaluate the morphological and functional characteristics of both the LV and RV in children diagnosed with LVNC.
  • To compare cardiac magnetic resonance (CMR) imaging findings and myocardial strain parameters between pediatric LVNC patients and healthy controls.

Main Methods:

  • A case-control study involving 16 pediatric patients with LVNC and 16 matched healthy controls.
  • Cardiovascular magnetic resonance (CMR) was used to assess LV and RV morphology and function.
  • Tissue-tracking analysis quantified global radial (GRS), circumferential (GCS), and longitudinal strain (GLS) for both ventricles.

Main Results:

  • Pediatric LVNC patients exhibited higher indexed end-diastolic volume (EDV), reduced ejection fraction (EF), and impaired LV strain compared to controls.
  • While RV ejection fraction and volume were similar, patients showed increased RV apical trabeculation.
  • Subclinical impairment in RV global radial strain (GRS) and global circumferential strain (GCS) was observed in children with LVNC.

Conclusions:

  • Pediatric LVNC is associated with left ventricular enlargement and systolic dysfunction.
  • The condition also involves increased right ventricular trabeculations and subclinical deficits in RV myocardial deformation.
  • CMR and strain analysis are valuable tools for assessing biventricular involvement in pediatric LVNC.

Keywords:
cardiovascular magnetic resonancechildrenlate gadolinium enhancementleft ventricular non-compactionstraintissue-tracking

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