Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

2.2K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
2.2K
T Cell Types and Functions01:24

T Cell Types and Functions

1.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.5K
Antigen Processing Pathways01:31

Antigen Processing Pathways

1.4K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
1.4K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

747
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
747
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

7.4K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
7.4K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

74.7K
Overview
74.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TOP1MT rs2293925 is an enhancer-active regulatory SNP that shapes mitochondrial R-loop dynamics.

The FEBS journal·2026
Same author

Regioselective Synthesis of 5-Substituted 3-(β-d-Glycopyranosyl)isoxazoles and -isoxazolines by 1,3-Dipolar Cycloaddition as Potential Anticancer Agents and Glycogen Phosphorylase Inhibitors.

International journal of molecular sciences·2025
Same author

Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation.

Cell death discovery·2025
Same author

Synthesis and Biological Profiling of Seven Heparin and Heparan Sulphate Analogue Trisaccharides.

Biomolecules·2024
Same author

The PARP inhibitor rucaparib blocks SARS-CoV-2 virus binding to cells and the immune reaction in models of COVID-19.

British journal of pharmacology·2024
Same author

Cytostatic Bacterial Metabolites Interfere with 5-Fluorouracil, Doxorubicin and Paclitaxel Efficiency in 4T1 Breast Cancer Cells.

Molecules (Basel, Switzerland)·2024

Related Experiment Video

Updated: Oct 2, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

14.8K

Antigen-Presenting Cells in Psoriasis.

Dóra Antal1, Shahrzad Alimohammadi2, Péter Bai1

  • 1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Life (Basel, Switzerland)
|February 25, 2022
PubMed
Summary
This summary is machine-generated.

Psoriasis is an autoimmune disease driven by T cells. Skin antigen-presenting cells (APCs) are crucial for initiating and sustaining the immune responses that cause psoriasis lesions.

Keywords:
antigen-presenting cellsautoantigenskeratinocytemast cellneuropeptidepsoriasis

More Related Videos

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

15.5K

Related Experiment Videos

Last Updated: Oct 2, 2025

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

14.8K
An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

15.5K

Area of Science:

  • Immunology
  • Dermatology
  • Autoimmunity

Background:

  • Psoriasis is recognized as a T cell-mediated autoimmune skin disease.
  • Antigen-presenting cells (APCs) are central to the pathogenesis of psoriasis.
  • Skin APCs, including dendritic cells, Langerhans cells, monocytes, macrophages, keratinocytes, and mast cells, play a critical role.

Purpose of the Study:

  • To review the functional specialization of human skin APCs.
  • To elucidate the role of skin APCs in T cell activation and adaptive immunity during psoriasis.
  • To understand the initiation and onset of psoriasis.

Main Methods:

  • This is a review article.
  • Discussion of existing literature on skin APCs and psoriasis.

Main Results:

  • Skin APCs are key players in initiating and sustaining inflammatory responses in psoriasis.
  • Functional specialization of skin APCs promotes T cell activation.
  • APCs contribute to the development of psoriatic lesions and immune homeostasis.

Conclusions:

  • Skin APCs are integral to the pathogenesis of psoriasis.
  • Understanding skin APC function is vital for psoriasis research.
  • Targeting skin APCs may offer therapeutic strategies for psoriasis.