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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Does Locally Advanced Thyroid Cancer Have Different Features? Results from a Single Academic Center.

Marco Dell'Aquila1, Pietro Tralongo1, Giuseppe De Ruggieri2

  • 1Division of Anatomic Pathology and Histology, Fondazione Policlinico Universitario "Agostino Gemelli"-IRCCS, 00168 Rome, Italy.

Journal of Personalized Medicine
|February 25, 2022
PubMed
Summary

Locally advanced thyroid cancer (LATC), including papillary thyroid carcinoma (PTC) variants, shows aggressive behavior. These findings support more assertive management strategies for LATC patients to improve outcomes.

Keywords:
aggressivecancercarcinomagenetic alterationslocally advancedrecurrencethyroid

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Area of Science:

  • Oncology
  • Endocrinology
  • Surgical Pathology

Background:

  • 15% of differentiated thyroid cancers, including papillary thyroid carcinoma (PTC), present as locally advanced thyroid cancer (LATC).
  • LATC poses significant challenges due to risks of recurrence, metastasis, and reduced survival.
  • Understanding the characteristics of LATC is crucial for effective treatment planning.

Purpose of the Study:

  • To analyze a cohort of LATC patients.
  • To evaluate risks of local recurrence, distant metastases, and overall survival in LATC.
  • To identify factors influencing the clinical course of LATC.

Main Methods:

  • Retrospective analysis of 65 LATC patients diagnosed between 2010 and 2020.
  • Analysis of preoperative cytological samples from 42 patients.
  • Investigation of BRAF and TERT mutations in both cytology and histopathology specimens.

Main Results:

  • The cohort comprised 65% women, with a median age of 60.1 years.
  • Aggressive PTC variants, particularly tall cell variant (26.1%), were prevalent.
  • All patients had nodal metastases, and extrathyroidal extension was common, affecting the recurrent laryngeal nerve in 69.2%.

Conclusions:

  • Locally advanced thyroid cancers, including PTC variants, demonstrate a more aggressive biological profile.
  • These findings underscore the need for more assertive management strategies for LATC.
  • Timely and aggressive treatment may improve survival and reduce recurrence rates in LATC.