Flexible Neural Probes with Optical Artifact-Suppressing Modification and Biofriendly Polypeptide Coating

Area of Science:

• Neuroscience
• Biomaterials Engineering
• Electrical Engineering

Background:

• Optogenetics offers precise neuronal control but faces challenges with neural probes.
• Metal microelectrodes in probes generate photoelectric noise under optical stimulation, distorting neural signals.
• Improving the biocompatibility of neural probes is crucial for long-term implantation.

Purpose of the Study:

• To evaluate the electrochemical performance and photoelectric noise of modified neural probes.
• To identify optimal materials for flexible polyimide-based neural probes used in optogenetics.
• To enhance the biocompatibility of neural probes for improved neural recording.

Main Methods:

• Five types of neural interface materials were deposited on flexible polyimide probes.
• Probes were subjected to blue laser pulses to assess electrochemical performance and photoelectric noise.
• A double-layer composite (platinum-black/conductive polymer) and polypeptide coating were tested.

Main Results:

• Material modifications improved electrochemical performance and reduced photoelectric artifacts.
• The double-layer composite of platinum-black and conductive polymer exhibited superior performance.
• Polypeptide coating enhanced biocompatibility with minimal impact on electrochemical properties.

Conclusions:

• Modified neural probes demonstrate enhanced electrochemical stability and reduced noise for optogenetic applications.
• A platinum-black/conductive polymer composite offers a promising solution for neural interface challenges.
• Polypeptide coatings improve neural probe biocompatibility and offer potential for drug delivery.