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Quorum-Sensing Inhibition by Gram-Positive Bacteria
Evgeniya V Prazdnova1, Andrey V Gorovtsov1, Nikita G Vasilchenko1
1Academy of Biology and Biotechnology, Southern Federal University, 344090 Rostov-on-Don, Russia.
Microorganisms
|February 25, 2022
Summary
This review explores quorum-sensing suppression in Gram-positive microbes. It details mechanisms, molecular aspects, and applications in food, probiotics, and pathogen control.
Area of Science:
- Microbiology
- Molecular Biology
- Biotechnology
Background:
- Microbial communities communicate via regulatory mechanisms, influencing interactions like antagonism and biofilm formation.
- Quorum-quenching is a strategy to counteract microbial communication, involving the suppression of quorum-sensing systems.
- Gram-positive microorganisms play key roles in food fermentation, as probiotics, and in various biotechnological applications.
Purpose of the Study:
- To review quorum-sensing suppression mechanisms in Gram-positive microorganisms.
- To elucidate the molecular intermediates and underlying processes of quorum-quenching.
- To discuss the evolutionary significance and practical applications of quorum-quenching.
Main Methods:
- Literature review focusing on quorum-sensing and quorum-quenching mechanisms.
- Analysis of molecular pathways involved in signal interference and degradation.
- Examination of studies on Gram-positive bacteria with biotechnological relevance.
Main Results:
- Gram-positive microorganisms employ diverse strategies to suppress quorum-sensing, involving specific enzymes and molecular intermediates.
- Quorum-quenching mechanisms are crucial for regulating interspecies interactions and controlling microbial populations.
- Identified molecular players offer insights into the evolutionary development of microbial communication.
Conclusions:
- Quorum-sensing suppression is a vital mechanism in Gram-positive bacteria with significant biotechnological potential.
- Understanding these mechanisms can lead to novel strategies for pathogen control, enhanced probiotic efficacy, and improved plant protection.
- Further research into quorum-quenching can unlock new applications in industrial microbiology and sustainable agriculture.
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