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Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Hemoglobin01:24

Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Microbial Nutrition01:28

Microbial Nutrition

Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
Anoxygenic Phototrophic Bacteria01:28

Anoxygenic Phototrophic Bacteria

Anoxygenic phototrophic bacteria are a diverse group of microorganisms that perform photosynthesis without producing oxygen. They primarily include purple sulfur bacteria, purple nonsulfur bacteria, green sulfur bacteria, and green nonsulfur bacteria. These bacteria are classified into the Gammaproteobacteria, Alphaproteobacteria, Betaproteobacteria, Chlorobi, and Chloroflexi lineages, each with distinct physiological and ecological adaptations.Purple sulfur bacteria belong to the...
Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...

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Updated: Jul 17, 2026

Staphylococcus aureus Growth using Human Hemoglobin as an Iron Source
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Final Thoughts, Microorganisms Special Issue on Microbial Hemoglobins.

Benjamin C Stark1

  • 1Department of Biology, Illinois Institute of Technology, Chicago, IL 60616, USA.

Microorganisms
|February 25, 2022
PubMed
Summary

Microbial hemoglobins, discovered 35 years ago, are vital proteins involved in oxygen transport and storage. Ongoing research continues to uncover their diverse functions and potential applications in biotechnology.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Molecular Biology

Background:

  • Microbial hemoglobins (Hbs) are heme-containing proteins found in various microorganisms.
  • Their discovery in 1986 by Dale Webster and colleagues opened new avenues in understanding non-vertebrate Hbs.

Discussion:

  • Microbial Hbs exhibit diverse structural and functional properties distinct from their animal counterparts.
  • These proteins play crucial roles in oxygen sensing, nitric oxide scavenging, and detoxification pathways.

Key Insights:

  • The 35th anniversary highlights the sustained interest and expanding knowledge of microbial Hbs.
  • Research reveals their significant involvement in microbial adaptation to changing environments.

Outlook:

  • Future research will likely focus on elucidating novel functions and engineering microbial Hbs for biotechnological applications.
  • Exploring their potential in areas like biosensing and bioremediation is a promising direction.