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Compact photothermal self-mixing interferometer for highly sensitive trace detection.

Zhen Huang, Beiqing Du, Zhenghe Zhang

    Optics Express
    |February 25, 2022
    PubMed
    Summary

    A novel photothermal self-mixing (PTSM) interferometer offers highly sensitive trace detection. This compact sensor achieved a 7.7 nM limit of detection for methylene blue, showing promise for analyzing photosensitive compounds.

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    Area of Science:

    • Analytical Chemistry
    • Spectroscopy
    • Optics

    Background:

    • Photothermal spectroscopy enables sensitive detection of analytes.
    • Self-mixing interferometers offer compact sensing solutions.
    • Integrating these techniques can enhance analytical capabilities.

    Purpose of the Study:

    • To develop and characterize a novel photothermal self-mixing (PTSM) interferometer for trace detection.
    • To utilize a single He-Ne laser as excitation, probe, and detector.
    • To assess the metrological performance of the PTSM interferometer.

    Main Methods:

    • A photothermal spectroscopy setup was integrated with a self-mixing interferometer.
    • External cavity modulation was employed in the PTSM interferometer.
    • Methylene blue was used as a model analyte for performance evaluation.

    Main Results:

    • The PTSM interferometer directly measured sample concentration via the PTSM parameter.
    • A limit of detection of 7.7 nM for methylene blue was achieved with 5 mW excitation power.
    • A relative standard deviation of approximately 3% was obtained, indicating good precision.

    Conclusions:

    • The developed PTSM interferometer is a sensitive and robust analytical tool.
    • Its compact and simple design is advantageous for practical applications.
    • The sensor shows potential for detecting photosensitive compounds and aquatic hazards.