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Updated: Oct 2, 2025

Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors
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Highly accurate THz-CT including refraction effects.

Peter Fosodeder, Sandrine van Frank, Christian Rankl

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    |February 25, 2022
    PubMed
    Summary

    This study introduces a new algebraic image reconstruction method for terahertz computed tomography (THz-CT) that accounts for sample refraction. The developed algorithm achieves high accuracy, with reconstructed sample cross sections showing less than 150 μm error.

    Area of Science:

    • Physics
    • Optics
    • Imaging Science

    Background:

    • Terahertz computed tomography (THz-CT) traditionally faces challenges with accurate image reconstruction due to sample refraction.
    • Existing methods may not fully account for the complex optical properties of materials at terahertz frequencies.

    Purpose of the Study:

    • To develop and validate a novel algebraic image reconstruction algorithm for THz-CT that incorporates sample refraction.
    • To improve the accuracy and robustness of THz-CT imaging by utilizing geometric optics principles.

    Main Methods:

    • Applied algebraic image reconstruction principles to THz-CT.
    • Developed a reconstruction algorithm based on geometric optics, using nominal sample geometry as prior knowledge.
    • Verified the geometric forward model via numerical simulation of Maxwell's equations.

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  • Experimentally tested the method using a fast THz-CT system with a THz time-domain spectrometer.

    • Main Results:

    • Presented a highly accurate and robust image reconstruction algorithm for THz-CT.
    • Demonstrated the validity of the geometric forward model through simulations.
    • Experimental validation showed reconstructed sample cross sections with an accuracy of less than 150 μm.

    Conclusions:

    • The developed algebraic reconstruction method effectively accounts for refraction in THz-CT.
    • The algorithm offers a significant improvement in accuracy for THz imaging applications.
    • This approach enhances the utility of THz-CT for material analysis and non-destructive testing.