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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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Challenges in the Use of Targeted Therapies in Non-Small Cell Lung Cancer

Joel Rivera-Concepcion1, Dipesh Uprety2, Alex A Adjei1

  • 1Department of Oncology, Mayo Clinic, Rochester, MN, USA.

Cancer Research and Treatment
|February 25, 2022
PubMed

Insights

Precision oncology is transforming cancer care, especially for advanced non-small cell lung cancer (NSCLC). This review discusses challenges and future strategies for targeted therapies in NSCLC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Precision oncology has revolutionized cancer diagnosis and treatment.
  • Management of advanced non-small cell lung cancer (NSCLC) has shifted towards molecularly targeted drugs.
  • Identifiable oncogene drivers are increasing, leading to new therapeutic options.

Purpose of the Study:

  • To review the major challenges associated with targeted therapies in NSCLC.
  • To provide guidance for future strategies in the use of targeted therapies for NSCLC.

Main Methods:

  • Literature review of recent advancements in precision oncology for NSCLC.
  • Analysis of challenges including drug toxicities, resistance, access, and costs.
  • Synthesis of current data to inform future therapeutic approaches.

Main Results:

  • Targeted therapies have shown significant safety and efficacy in NSCLC.
  • Key challenges include managing drug toxicities, overcoming resistance, and ensuring patient access and affordability.
  • The future of thoracic oncology emphasizes molecular testing and targeted treatments.

Conclusions:

  • Targeted therapies represent a paradigm shift in NSCLC management.
  • Addressing challenges in toxicity, resistance, access, and cost is crucial for optimal utilization.
  • Continued research and strategic planning are essential for advancing precision oncology in NSCLC.
Keywords:
ChallengesCostDrug resistanceLung neoplasmsNSCLCNon-small cell lung cancerTargeted therapy

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