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Anticancer Mechanisms of Berberine: A Good Choice for Glioblastoma Multiforme Therapy
Bahram Bibak1,2, Farzaneh Shakeri1,2, Zakieh Keshavarzi1,2
1Natural Products and Medicinal Plants Research Center, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Abstract:
The most typical malignant brain tumor, glioblastoma multiforme (GBM), seems to have a grim outcome, despite the intensive multi-modality interventions. Literature suggests that biologically active phytomolecules may exert anticancer properties by regulating several signaling pathways. Berberine, an isoquinoline alkaloid, has various pharmacological applications to combat severe diseases like cancer. Mechanistically, it inhibits cell proliferation and invasion, suppresses tumor angiogenesis, and induces cell apoptosis. The antitumoral effect of berberine in GBM is increasingly recognized. This review sheds new light on the regulatory signaling mechanisms of berberine in various cancers, proposing its potential role as a therapeutic agent for GBM.
Insights
Berberine, a natural compound, shows promise in fighting glioblastoma multiforme (GBM). This review explores how berberine may offer a new therapeutic strategy for this aggressive brain cancer.
Area of Science:
- Oncology
- Pharmacology
- Biochemistry
Background:
- Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis despite treatment.
- Phytomolecules, like berberine, are being investigated for their anticancer potential.
- Berberine is a natural alkaloid with demonstrated anti-cancer properties.
Purpose of the Study:
- To review the signaling mechanisms of berberine in various cancers.
- To evaluate the potential of berberine as a therapeutic agent for glioblastoma multiforme.
Main Methods:
- Literature review of studies on berberine's effects on cancer signaling pathways.
- Analysis of berberine's inhibitory effects on cell proliferation, invasion, angiogenesis, and induction of apoptosis.
Main Results:
- Berberine exhibits anti-proliferative, anti-invasive, and anti-angiogenic effects.
- Berberine induces apoptosis in cancer cells.
- Evidence suggests berberine's antitumoral activity in GBM is significant.
Conclusions:
- Berberine demonstrates multifaceted anticancer mechanisms.
- Berberine holds potential as a novel therapeutic agent for glioblastoma multiforme.
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